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Vitamin A
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Iron
/ Complex Formation:
... Each red blood cell is full of 250 million haemoglobin molecules, each haemoglobin molecule has four Fe(II)-haem groups, which can accept an oxygen molecule each, giving a grand total of 1000 million oxygen molecules transported by each red blood cell. ... [20/06/01]
http://www.chm.bris.ac.uk/webprojects2001/grassby/iron.htm |
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A bloodless revolution
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SEARCH
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... "We have also introduced multiple modifications of the distal haem pocket in order to control NO reactivity and thereby reduce this adverse hypertensive effect. ... "
Sangart focuses on Hb-based oxygen carriers from a different perspective. ...
http://www.nature.com/embor/journal/v6/n8/full/7400494.html |
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4.

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EiC July 2006 - Feature - Artemisinin and a new generation of antimalarial drugs
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/ Other RSC site areas... ... Substantial quantities of reactive iron(II) accumulate inside an infected red blood cell as a result of the liberation of the haem group, which is a byproduct of the digestion of haemoglobin. ... 1. A. Butler and T. Hensman, Educ. ...
http://www.rsc.org/Education/EiC/issues/2006July/Artemisinin.asp |
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Biochemical Society Symposia Volume 71 Chapter 14 - Roberta Foresti et. al. - Generation of bile pigments by haem oxygenase: a refined cellular strategy in resp
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... The family of haem oxygenase enzymes is unique in nature for its role in haem degradation. Haem is cleaved at the a-meso position by haem oxygenase with the support of electrons donated by cytochrome P450 reductase, the first products of this reaction being CO, iron and biliverdin. ...
http://symposia.biochemistry.org/bssymp/071/bss0710177.htm |
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Dr L.L. Wong
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Department of Chemistry
... Our aim is to examine the specific features of haem proteins which promote their catalytic activities, using myoglobin as a model. ... A single amino acid change we have made improves the catalytic activity of myoglobin, to a level comparable with naturally occurring haem enzymes. 2. ... [19/09/07]
http://www.chem.ox.ac.uk/researchguide/llwong.html |
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Mechanism of disease: Portrait of anaemia in sir zebrafish - Cell Signaling Update - Signaling Gateway
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... A group of scientists studying a zebrafish mutant, the shiraz (sir) mutant, have uncovered a link between two important pathways — the formation of Fe–S clusters and the production of haem. ... Wild-type and sir zebrafish embryos have provided a clearer picture of the control of haem synthesis. ...
http://www.signaling-gateway.org/update/updates/200510/nrm1751.html |
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Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease.
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... BACKGROUND: A functional GT dinucleotide length polymorphism in the haem oxygenase-1 (HO-1) gene promoter is thought to be involved in the pathogenesis of cardiovascular disease. ... It is not intended to be a substitute for professional care. ...
http://www.leaddiscovery.co.uk/admin%20cv/files/8694.asp |
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2.6 Structural studies of enzymes involved in Vitamin B12 biosynthesis
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2.6 Structural studies of enzymes involved in Vitamin B12 biosynthesis
... Sirohaem is a modified tetrapyrrole that is structurally related to haem, chlorophyll and cobalamin and is the prosthetic group required in the six-electron reduction of both sulphite and nitrite. ... [23/11/04]
http://www.ysbl.york.ac.uk/projects/2/2.6.htm |
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Genome Biology |Full text |Cytochromes P450: a success story
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29-Jun-2007
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... P450 enzymes have been compared to a blowtorch. ... 22. Li H, Poulos TL: The structure of the cytochrome P450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid. ... The place to see a model of P450 insertion in a membrane. 37. ... Post a comment on this article! ...
http://genomebiology.com/2000/1/6/reviews/3003 |
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